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Aging and the rising incidence of associated diseases are among the major health and social problems facing humanity.
During the “13th Five-Year Plan” period, China’s aging research achieved remarkable results. Liu Guanghui, a researcher at the Institute of Zoology of the Chinese Academy of Sciences and deputy dean of the Institute of Stem Cells and Innovation in Regenerative Medicine of the Chinese Academy of Sciences, and his research team discovered a molecular switch to slow down The rate of cell aging.
The scientific team cultured and examined tens of millions of human cells for seven years, and verified dozens of undiscovered genes that can promote cell aging out of more than 20,000 human genes.
After repeated examinations, the presence of a new human aging-promoting gene called KAT7 was finally confirmed.
Experiments confirmed that partial inactivation of the gene in the livers of aged mice could make 81% of mice live past more than 130 weeks, which is equivalent to approximately 80 years in humans.
This discovery is a major breakthrough in the biology of aging research.
Based on the dozens of genes that affect aging recently discovered by this research, the research team has compiled the most complete list of human aging-promoting genes in the world.
In this regard, the Chinese “People” newspaper quoted Liu Guanghui as saying: “We have systematically analyzed the basic mechanisms leading to organ aging, and found that caloric restriction can reduce chronic inflammation and delay aging. Cell aging is the main cause of body aging. In the future, we aspire to adopt scientific assessments of aging and pharmacological, genetic, cellular and other interventions to help achieve healthy aging.”
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