Last week, Oregon State University became famous not only in the Czech political arena, but also in the field of research cannabinoid And its effect on SARS-CoV-2 virus. Cannabis is found in the breast milk of mammals, including humans, but we usually associate it primarily with cannabis.
And only of vegetable origin In the article (PDF) Researchers from the Oregon State University School of Pharmacy and colleagues at Oregon Health & Science University (OHSU) also conducted research in the Journal of Natural Products to investigate what happens when primary cannabis is used. cannabigruolic acid (CBGA) molecule and its complex carboxylic acids THCA a CBDA come into contact with the virus.
Cannabinoids as an antiviral adhesive
During the experiment, all of the mentioned cannabinoids, with varying degrees of success, acted as adhesives and bind to virus particles that cannot penetrate the epithelial cells that make up our mucous membranes.
Computational model of different isoforms of binding of CBGA, CBGA, and THCA molecules to the yellow residue of the SARS-CoV-2 virus spike protein.
How is that possible? In fact, this was not surprising, and for hemp, the researchers did not choose from ordinary peas and because they had enough in their pockets. Their suitability was previously confirmed by mass spectrometry, according to which the cannabinoid acid molecules have a suitable shape and can be suits into important parts of the virus as two puzzle pieces.
Hemp attacks spike protein
This was finally verified by tests with some modified variants and some older variants of SARS-CoV-2 (alpha B.1.1.7 and also beta B.1.351), in which the cannabinoid acid molecules related The spike protein of the SARS-CoV-2 virus, now widely known and still quoted.
CBDA and CBGA gradually neutralize virus spike protein under laboratory conditions
According to the experiment, CBDA and CBGA acid molecules performed better, which, when glued together, changed the shape of the virus in such a way that it could no longer penetrate the cell and cause infection.
Thus, the socially stigmatized plant has again been confirmed to be the source of a unique blend of substances that could have additional and previously unforeseen pharmacological potential in the future.
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