Pakistan Christian TV

Breaking news and world news from Pakisthan Christian TV on Business, Sports, Culture. Video news. News from the US, Europe, Asia Pacific, Africa, Middle East, America.

Why are some people naturally less resistant to COVID-19?

the health Christoph Bergstede / Science Image Library

expressive image

A team of researchers affiliated with a group of institutions in the UK and Brazil has, in part, solved the mystery of why some are naturally less resistant to COVID-19 than others.

A new study shows that small differences in an individual’s genetic makeup may help explain why some people build a strong natural defense against Covid infection, while others become severely ill.

read more

What do you eat when you have

Researchers at the University of Glasgow’s Center for Virus Research have identified a specific protein called OAS1, which is thought to play a key role in shaping the early stages of an individual’s response to Sars-CoV-2.

When a human cell is infected, the OAS1 protein interacts with interferon signaling by inviting an immune response upon detection of SARS-CoV-2, allowing the cell to begin attacking the virus’ genetic material.

Previous studies have also shown that these signals can inhibit SARS-CoV-2 replication.

The study, published in Science, reports that some people express a more protective version of OAS1 that binds to membranes using a prenyl group as part of the signaling process, which is the addition of a single lipid molecule to the protein encoded by the OAS1 gene.

Because coronaviruses burrow inside cells and replicate their genomes inside lipid-formed vesicles, pre-OAS1 is more suitable to search for Sars-CoV-2 and direct cellular weapons to attack it.

The researchers looked at copies of 500 COVID-19 patients who had a wide range of symptoms, and found that those who had not been exposed to prior OAS1 experienced more severe symptoms. Why some people are born without this enzyme is still a mystery, but the team’s work could help lead to new types of vaccines against “Covid-19” and other types of infections.

According to their findings, the researchers turned their attention to another mammal, the horseshoe bat, one of the putative sources of SARS-CoV-2, and found that it does not possess the OAS1 preform that protects humans from the virus. This finding could help explain why bats are such prolific hosts for a variety of viruses.

This means that the virus never needed to adapt to evade this line of defense, but if SARS-CoV-2 mutates and gains the ability to circumvent the defenses generated by OAS1 priming, the virus could potentially become more lethal or transmissible.

Source: The Independent